MEDILOT (loteprednol etabonate ophthalmic suspension 0.5%) is a sterile ophthalmic suspension. Loteprednol etabonate is a topical anti-inflammatory corticosteroid for ophthalmic use. Loteprednol etabonate is a white to off-white powder. Corticosteroids inhibit the inflammatory response to a variety of inciting agents and probably delay or slow healing. They inhibit the edema, fibrin deposition, capillary dilation, leukocyte migration, capillary proliferation, fibroblast proliferation, deposition of collagen, and scar formation associated with inflammation. There is no generally accepted explanation for the mechanism of action of ocular corticosteroids. Corticosteroids are capable of producing a rise in intraocular pressure. Loteprednol etabonate is structurally similar to other corticosteroids. However, the number 20 position ketone group is absent. It is highly lipid soluble which enhances its penetration into cells. Loteprednol etabonate is synthesized through structural modifications of prednisolone-related compounds so that it will undergo a predictable transformation to an inactive metabolite.
MEDILOT ophthalmic suspension 0.5% is indicated for the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea and anterior segment of the globe such as allergic conjunctivitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, selected infective conjunctivitis, when the inherent hazard of steroid use is accepted to obtain an advisable diminution in edema and inflammation. MEDILOT Ophthalmic Suspension 0.5% should not be used in patients who require a more potent corticosteroid for this indication.
MEDILOT ophthalmic suspension 0.5% is also indicated for the treatment of post-operative inflammation following ocular surgery.
Apply one drop of MEDILOT® ophthalmic suspension 0.5% into the conjunctival sac of the affected eye four times daily. During the initial treatment within the first week, the dosing may be increased, up to 1 drop every hour, if necessary. Care should be taken not to discontinue therapy prematurely.
Post-Operative Inflammation: Apply one drop of MEDILOT Ophthalmic Suspension 0.5% into the conjunctival sac of the operated eye four times daily beginning 24 hours after surgery and continuing throughout the first 2 weeks of the post-operative period.
MEDILOT (loteprednol etabonate ophthalmic suspension) 0.5% is supplied sterile in opaque white LDPE plastic bottle with dropper with pink high impact polystyrene (HIPS) cap in 5ml pack.